I started on Mevacor back in March; 3 wks. into it, my feet and legs hurt so bad I could hardly walk. Switched to Lopid; same thing 2 wks. later. Then came Zetia, with no reprieve. Finally, Zocor, and I had such bad cramps in my calves that I finally said enough. I'm trying the RYR and so far no ill effects...we'll see how it goes. (Interesting note...the day after I stopped the Zocor, my ankles stopped swelling, and I got rid of alot of fluid. Anyone else had this happen?)